Xi'an App Chem-Bio (Tech) Co., Ltd

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	Camptothecin

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[English Name]: Camptothecin

[Chemical Name]: 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]

indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione

[Product Resource]: From fruit and leaves of the plant Camptotheca acurminata (Camptotheca, Happy tree), a tree native in China.

[Structure Formula]:

[Molecular Formula]: C₂₀H₁₆N₂O₄

[Molecular Weight]: 348.36

[CAS Number]: 7689-03-4

[Specification]: 95ï½99%ï¼HPLC)

[Properties]: light yellow needle crystal.

[Application Scope]: antitumour, immunosuppressant, antivirus.

[Other Information]: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomeraseI (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and advers drug reaction. Because of these disadvantages researchers have made numbers of derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.

[Package]: 5g in Plastic bags.

[Validity]: two year, kept in cool and dry places.